NOVEL 7-DEAZAPURINE INCORPORATING ISATIN HYBRID COMPOUNDS AS PROTEIN KINASE INHIBITORS: DESIGN, SYNTHESIS, IN SILICO STUDIES, AND ANTIPROLIFERATIVE EVALUATION

Cancer is a Beach Shorts multifactorial disorder with extremely complex genetics and progression.The major challenge in cancer therapy is the development of cancer resistance and relapse.Conventional anticancer drugs directly target the DNA of the cell, while modern chemotherapeutic drugs include molecular-targeted therapy, such as targeting the ab

Abstract Background Common causes of air leakage around an endotracheal tube include insufficient endotracheal tube cuff inflation and damage to the Apparel Accessories cuff, while damage to the pilot balloon or pilot balloon tubing is relatively rare.Case presentation A 74-year-old female with vertebral osteomyelitis was scheduled for an extreme l

Purpose: Hormone Replacement Therapy (HRT) is important for gender reassignment procedures for Plush transgender persons in India.The study explores practices of male-to-female transgenders to access HRT for feminization procedures in Maharashtra, India.Methods: The first participant for this qualitative exploratory study was recruited from a commu